Dataset Information

The Use of Instructive Feedback to Promote Emergent Tact and Intraverbal Control: A Replication.

ABSTRACT: Instructive feedback (IF) involves incorporating additional acquisition targets into skill-acquisition programs. A recent study by Frampton and Shillingsburg (2020) found that IF led to emergent verbal operants with two elementary-aged children diagnosed with autism spectrum disorder (ASD). The current study replicated Frampton and Shillingsburg with two children with ASD. Therapists conducted sessions of mastered listener-by-name trials (e.g., "Show me otter," with pictures of otter, dog, and elephant) with IF statements for features of the target stimuli (e.g., "It lives in rivers.") embedded during the consequence portion of the trial. We evaluated the acquisition of secondary targets and emergent responses using a concurrent multiple baseline across sets design. We observed increased correct responding for secondary targets and emergent responses for all three sets of stimuli with one participant. The other participant emitted correct responses for secondary targets and emergent operants with the first set but not with the other two sets of stimuli. Results suggested that IF can lead to emergent verbal operants, but the extent of emergence may be idiosyncratic.

Supplementary information

The online version contains supplementary material available at 10.1007/s40616-022-00171-y.

SUBMITTER: Gavidia VL

PROVIDER: S-EPMC9255526 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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The Use of Instructive Feedback to Promote Emergent Tact and Intraverbal Control: A Replication.

Gavidia Valeria Laddaga VL Bergmann Samantha S Rader Karen A KA

The Analysis of verbal behavior 20220705 2

Instructive feedback (IF) involves incorporating additional acquisition targets into skill-acquisition programs. A recent study by Frampton and Shillingsburg (2020) found that IF led to emergent verbal operants with two elementary-aged children diagnosed with autism spectrum disorder (ASD). The current study replicated Frampton and Shillingsburg with two children with ASD. Therapists conducted sessions of mastered listener-by-name trials (e.g., "Show me otter," with pictures of otter, dog, and e ...[more]

PMID: 35811687

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Project description:BackgroundAge-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly patients.MethodsPoly(L-lactide-co-ɛ-caprolactone) (PLCA) scaffolds are functionalized with plant-derived nanoparticles from potato, rhamnogalacturonan-I (RG-I), to investigate their ability to modulate inflammation in vitro in neutrophils and macrophages at gene and protein levels. The scaffolds' early and late host response at gene, protein and histological levels is tested in vivo in a subcutaneous rat model and their potential to promote bone regeneration in an aged rodent was tested in a critical-sized calvaria bone defect. Significant differences were tested using one-way ANOVA, followed by a multiple-comparison Tukey's test with a p value ≤ 0.05 considered significant.ResultsGene expressions revealed PLCA scaffold functionalized with plant-derived RG-I with a relatively higher amount of galactose than arabinose (potato dearabinated (PA)) to reduce the inflammatory state stimulated by bacterial LPS in neutrophils and macrophages in vitro. LPS-stimulated neutrophils show a significantly decreased intracellular accumulation of galectin-3 in the presence of PA functionalization compared to Control (unmodified PLCA scaffolds). The in vivo gene and protein expressions revealed comparable results to in vitro. The host response is modulated towards anti-inflammatory/ healing at early and late time points at gene and protein levels. A reduced foreign body reaction and fibrous capsule formation is observed when PLCA scaffolds functionalized with PA were implanted in vivo subcutaneously. PLCA scaffolds functionalized with PA modulated the cytokine and chemokine expressions in vivo during early and late inflammatory phases. PLCA scaffolds functionalized with PA implanted in calvaria defects of aged rats downregulating pro-inflammatory gene markers while promoting osteogenic markers after 2 weeks in vivo.ConclusionWe have shown that PLCA scaffolds functionalized with plant-derived RG-I with a relatively higher amount of galactose play a role in the modulation of inflammatory responses both in vitro and in vivo subcutaneously and promote the initiation of bone formation in a critical-sized bone defect of an aged rodent. Our study addresses the increasing demand in bone tissue engineering for immunomodulatory 3D scaffolds that promote osteogenesis and modulate immune responses.

Dataset Information

The Use of Instructive Feedback to Promote Emergent Tact and Intraverbal Control: A Replication.

Supplementary information

Publications

The Use of Instructive Feedback to Promote Emergent Tact and Intraverbal Control: A Replication.

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