A Comprehensive Analysis for Expression, Diagnosis, and Prognosis of m⁵C Regulator in Breast Cancer and Its ncRNA-mRNA Regulatory Mechanism.

ABSTRACT: Recent studies have well demonstrated that 5-methylcytosine (m⁵C) regulators play pivotal roles in pathological conditions, including cancer. This study first tried to identify potential 5-methylcytosine (m⁵C) regulators in breast cancer by combination of expression, diagnosis, and survival analyses, and then established an ncRNA-mRNA network accounting for m⁵C regulators' roles in breast cancer. Among 13 m⁵C regulators, DNMT3B and ALYREF were significantly upregulated in breast cancer and their high expression indicated unfavorable prognosis. Both DNMT3B and ALYREF possessed the statistical abilities to distinguish breast cancer from normal breast samples. Moreover, five potential upstream miRNAs (let-7b-5p, miR-195-5p, miR-29a-3p, miR-26a-5p, a

SUBMITTER: Liu J 

PROVIDER: S-EPMC9257136 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature