Identifying control ensembles for information processing within the cortico-basal ganglia-thalamic circuit.

ABSTRACT: In situations featuring uncertainty about action-reward contingencies, mammals can flexibly adopt strategies for decision-making that are tuned in response to environmental changes. Although the cortico-basal ganglia thalamic (CBGT) network has been identified as contributing to the decision-making process, it features a complex synaptic architecture, comprised of multiple feed-forward, reciprocal, and feedback pathways, that complicate efforts to elucidate the roles of specific CBGT populations in the process by which evidence is accumulated and influences behavior. In this paper we apply a strategic sampling approach, based on Latin hypercube sampling, to explore how variations in CBGT network properties, including subpopulation firing rates and synaptic weights, map to variability of pa

SUBMITTER: Vich C 

PROVIDER: S-EPMC9258830 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature