Ontology highlight
ABSTRACT:
SUBMITTER: Huang YJ
PROVIDER: S-EPMC9258878 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Huang Yu-Jyun YJ Wang Pei-Ming PM Tang Kuo-Shu KS Chen Chih-Jen CJ Huang Ying-Hsien YH Tiao Mao-Meng MM
PloS one 20220706 7
A maternal high-fat diet (HFD) can impact the offspring's development of liver steatosis, with fetal development in utero being a crucial period. Therefore, this study investigated the mechanism and whether butyrate can rescue liver injury caused by maternal HFD in the fetus. Pregnant female Sprague Dawley rats were randomly divided into two groups, prenatal HFD (58% fat) exposure or normal control diet (4.5% fat). The HFD group was fed an HFD 7 weeks before mating and during gestation until sac ...[more]