Comprehensive Analysis of the E2F Transcription Factor Family in Human Lung Adenocarcinoma.

ABSTRACT:

Background

E2F transcription factors (E2Fs), code a family of pivotal transcription factors, have been identified as key regulators in tumor tumorigenesis. However, the function of E2F family in human lung adenocarcinoma (LUAD) have not been fully elucidated.

Methods

Herein, The Cancer Genome Atlas (TCGA) databases, Kaplan-Meier plotter, cBioPortal and TIMER were used to analyze differential expression, prognostic value, genetic alteration and immune cell infiltration of E2Fs in LUAD patients.

Results

The expression levels of E2Fs (E2F1-8) were all significantly upregulated in LUAD tissues compared with normal lung tissues. All eight E2Fs had low rates of gene mutation in LUAD patients from cBioPortal databases. Survival analysis revealed that E2F

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9259060 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature