TGF-β1 is associated with deficits in cognition and cerebral cortical thickness in first-episode schizophrenia.

ABSTRACT:

Background

Evidence indicates that cytokines are associated with cognitive deficits in schizophrenia; however, the underlying brain-behaviour mechanisms remain unclear. We hypothesized that aberrations in brain structural connectivity mediate the cytokine effect in schizophrenia.

Methods

In this study, we recruited patients with first-episode schizophrenia (n = 75, average illness duration 12.3 months, average medication period 0.6 days) and healthy controls (n = 44) of both sexes. We first conducted whole-blood RNA sequencing to detect differentially expressed genes. We also explored transcriptomic data on the dorsal lateral prefrontal cortices (dlPFC) retrieved from the CommonMind Consortium for gene functional clustering; we measured plasma transforming grow

SUBMITTER: Pan S 

PROVIDER: S-EPMC9259382 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature