Associations of cognitive dysfunction with motor and non-motor symptoms in patients with de novo Parkinson's disease.

ABSTRACT: The risk factors of mild cognitive impairment (MCI) in patients with de novo Parkinson's disease (PD) remain unclear. Therefore, the objective of this study was to compare motor and non-motor symptoms between de novo patients with PD with and without MCI. Moreover, detailed relationships between each cognitive deficit and other clinical characteristics in de novo patients with PD were investigated. Consecutive patients with de novo PD were retrospectively enrolled in this study. Motor symptoms were assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) part-III and the Hoehn and Yahr (HY) stage. Non-motor symptoms including depression, anxiety, fatigue, and autonomic dysfunction were measured using representative questionnaires. Motor symptoms, depression, and dysautonomia wer

SUBMITTER: Kwon KY 

PROVIDER: S-EPMC9259652 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature