Unknown

Dataset Information

0

A brainstem circuit for nausea suppression.


ABSTRACT: Nausea is a discomforting sensation of gut malaise that remains a major clinical challenge. Several visceral poisons induce nausea through the area postrema, a sensory circumventricular organ that detects bloodborne factors. Here, we use genetic approaches based on an area postrema cell atlas to reveal inhibitory neurons that counteract nausea-associated poison responses. The gut hormone glucose insulinotropic peptide (GIP) activates area postrema inhibitory neurons that project locally and elicit inhibitory currents in nausea-promoting excitatory neurons through γ-aminobutyric acid (GABA) receptors. Moreover, GIP blocks behavioral responses to poisons in wild-type mice, with protection eliminated by targeted area postrema neuron ablation. These findings provide insights into the basic organization of nausea-associated brainstem circuits and reveal that area postrema inhibitory neurons are an effective pharmacological target for nausea intervention.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9260880 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5580810 | biostudies-literature
| S-EPMC10689238 | biostudies-literature
| S-EPMC6989100 | biostudies-literature
| S-EPMC6410737 | biostudies-literature
| S-EPMC6892811 | biostudies-literature
| S-EPMC7042728 | biostudies-literature
| S-EPMC9245928 | biostudies-literature
| S-EPMC4151326 | biostudies-literature
| S-EPMC9433108 | biostudies-literature
| S-EPMC10700140 | biostudies-literature