Ontology highlight
ABSTRACT:
SUBMITTER: Shrinidhi A
PROVIDER: S-EPMC9260944 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
ACS omega 20220623 26
Alkylation of aromatics and formation of a new C-C bond is usually achieved by the electrophilic attack of an activated carbon species on an electron-rich aromatic ring. Herein, we report an alternative method for alkylation of aromatics via nucleophilic addition of enolates of active methylene compounds to 1,4-dehydrobenzene diradicals derived from enediynes cyclodec-1,5-diyne-3-ene, benzo[3,4]-cyclodec-1,5-diyne-3-ene, and cyclohexeno[3,4]-cyclodec-1,5-diyne-3-ene. The benzo-substituted enediy ...[more]