C-reactive Protein Elevation Is Associated With QTc Interval Prolongation in Patients Hospitalized With COVID-19.

ABSTRACT:

Background

The relationship between inflammation and corrected QT (QTc) interval prolongation is currently not well defined in patients with COVID-19.

Objective

This study aimed to assess the effect of marked interval changes in the inflammatory marker C-reactive protein (CRP) on QTc interval in patients hospitalized with COVID-19.

Methods

In this retrospective cohort study of hospitalized adult patients admitted with COVID-19 infection, we identified 85 patients who had markedly elevated CRP levels and serial measurements of an ECG and CRP during the same admission. We compared mean QTc interval duration, and other clinical and ECG characteristics between times when CRP values were high and low. We performed mixed-effects linear regression analysis to identify associ

SUBMITTER: Isakadze N 

PROVIDER: S-EPMC9261932 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature