Ontology highlight
ABSTRACT:
SUBMITTER: Lai FTT
PROVIDER: S-EPMC9262887 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Lai Francisco T T FTT Yip Benjamin H K BHK Hunter David J DJ Rabago David P DP Mallen Christian D CD Yeoh Eng-Kiong EK Wong Samuel Y S SYS Sit Regina Ws RW
Scientific reports 20220707 1
Metformin has been shown to modulate meta-inflammation, an important pathogenesis in knee osteoarthritis (OA). The study aimed to test the association between regular metformin use with total knee replacement (TKR) in patients with diabetes. This is a retrospective study with electronic records retrieved in Hong Kong public primary care. Patients with diabetes aged ≥ 45 who visited during 2007 to 2010, were followed up for a four-year period from 2011 to 2014 to determine the incidence of TKR. P ...[more]