Ontology highlight
ABSTRACT:
SUBMITTER: Jang D
PROVIDER: S-EPMC9264316 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Jang Derek D Tang Jie J Schwendeman Steven P SP Prausnitz Mark R MR
ACS applied materials & interfaces 20220622 26
Microneedle (MN) patches enable simple self-administration of drugs via the skin. In this study, we sought to deliver drug-loaded microspheres (MSs) using MN patches and found that the poly(lactic-<i>co</i>-glycolic acid) (PLGA) MSs failed to localize in the MN tips during fabrication, thereby decreasing their delivered dose and delivery efficiency into skin. We determined that surface interactions between the hydrophobic MSs and the poly(dimethylsiloxane) (PDMS) mold caused MSs to adhere to the ...[more]