Risk and benefit for umbrella trials in oncology: a systematic review and meta-analysis.

ABSTRACT:

Background

Umbrella clinical trials in precision oncology are designed to tailor therapies to the specific genetic changes within a tumor. Little is known about the risk/benefit ratio for umbrella clinical trials. The aim of our systematic review with meta-analysis was to evaluate the efficacy and safety profiles in cancer umbrella trials testing targeted drugs or a combination of targeted therapy with chemotherapy.

Methods

Our study was prospectively registered in PROSPERO (CRD42020171494). We searched Embase and PubMed for cancer umbrella trials testing targeted agents or a combination of targeted therapies with chemotherapy. We included solid tumor studies published between 1 January 2006 and 7 October 2019. We measured the risk using drug-related grade 3 or higher advers

SUBMITTER: Strzebonska K 

PROVIDER: S-EPMC9264503 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature