Actual, Personalized Approaches to Preserve Cognitive Functions in Brain Metastases Breast Cancer Patients.

ABSTRACT: Breast cancer (BC) is the most often diagnosed cancer among women worldwide and second most common cause of brain metastases (BMs) among solid malignancies being responsible for 10-16% of all BMs in oncological patients. Moreover, BMs are associated with worse prognosis than systemic metastases. The quality of life (QoL) among brain metastases breast cancer (BMBC) patients is significantly influenced by cognitive functions. Cancer-related cognitive deficits and the underlying neural deficits in BMBC patients can be caused via BMs per se, chemotherapy administration, brain irradiation, postmenopausal status, or comorbidities. Brain RT often leads to cognitive function impairment by damage of neural progenitor cells of the hippocampus and hence decreased QoL. Sparing the hippocampal region o

SUBMITTER: Konopka-Filippow M 

PROVIDER: S-EPMC9265102 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature