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The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.

ABSTRACT: There is evidence that the concomitance of psoriasis and obesity may originate from the interplay between multiple genetic pathways and involve gene-gene interactions. The aim of this study was to compare the genetic background related to obesity among psoriatic patients versus healthy controls by means of a Genome-Wide Association Study (GWAS). A total of 972 psoriatic patients and a total of 5878 healthy donors were enrolled in this study. DNA samples were genotyped for over 500,000 single nucleotide polymorphisms (SNPs) using Infinium CoreExome BeadChips (Illumina, San Diego, CA, USA). Statistical analysis identified eleven signals (p < 1 × 10^-5) associated with BMI across the study groups and revealed a varying effect size in each sub-cohort. Seven of the alternative alleles (rs1558902 in the FTO gene, rs696574 in the CALCRL gene, as well as rs10968110, rs4551082, rs4609724, rs9320269, and rs2338833,) are associated with increased BMI among all psoriatic patients and four (rs1556519 in the ITLN2 gene, rs12972098 in the AC003006.7 gene, rs12676670 in the PAG1 gene, and rs1321529) are associated with lower BMI. The results of our study may lead to further insights into the understanding of the pathogenesis of obesity among psoriatic patients.

SUBMITTER: Kisielnicka A

PROVIDER: S-EPMC9266424 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.

Kisielnicka Anna A Sobalska-Kwapis Marta M Purzycka-Bohdan Dorota D Nedoszytko Bogusław B Zabłotna Monika M Seweryn Michał M Strapagiel Dominik D Nowicki Roman J RJ Reich Adam A Samotij Dominik D Szczęch Justyna J Krasowska Dorota D Bartosińska Joanna J Narbutt Joanna J Lesiak Aleksandra A Barasińska Paulina P Owczarczyk-Saczonek Agnieszka A Czerwińska Joanna J Szepietowski Jacek C JC Batycka-Baran Aleksandra A Czajkowski Rafał R Górecka-Sokołowska Magdalena M Rudnicka Lidia L Czuwara Joanna J Szczerkowska-Dobosz Aneta A

International journal of molecular sciences 20220702 13

There is evidence that the concomitance of psoriasis and obesity may originate from the interplay between multiple genetic pathways and involve gene−gene interactions. The aim of this study was to compare the genetic background related to obesity among psoriatic patients versus healthy controls by means of a Genome-Wide Association Study (GWAS). A total of 972 psoriatic patients and a total of 5878 healthy donors were enrolled in this study. DNA samples were genotyped for over 500,000 single nuc ...[more]

PMID: 35806402

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Project description:BackgroundDental caries is one of the most common chronic diseases and is influenced by a complex interplay of genetic and environmental factors. Most previous genetic studies of caries have focused on identifying genes that contribute to dental caries in specific ethnic groups, usually of European descent.MethodsThe aim of this study is to conduct a genome-wide association study (GWAS) to identify associations affecting susceptibility to caries in a large multiethnic population from Argentina, the Philippines, Guatemala, Hungary, and the USA, originally recruited for studies of orofacial clefts (POFC, N = 3686). Ages of the participants ranged from 2 to 12 years for analysis of the primary dentition, and 18-60 years for analysis of the permanent dentition. For each participant, dental caries was assessed by counts of decayed and filled teeth (dft/DFT) and genetic variants (single nucleotide polymorphisms, SNPs) were genotyped or imputed across the entire genome. Caries was analyzed separately for the primary and permanent dentitions, with age, gender, and presence/absence of any type of OFC treated as covariates. Efficient Mixed-Model Association eXpedited (EMMAX) was used to test genetic association, while simultaneously accounting for relatedness and stratification.ResultsWe identified several suggestive loci (5 × 10-8 < P < 5 × 10-6) within or near genes with plausible biological roles for dental caries, including a cluster of taste receptor genes (TAS2R38, TAS2R3, TAS2R4, TASR25) on chromosome 7 for the permanent dentition analysis, and DLX3 and DLX4 on chromosome 17 for the primary dentition analysis. Genome-wide significant results were seen with SNPs in the primary dentition only; however, none of the identified genes near these variants have known roles in cariogenesis.ConclusionThe results of this study warrant further investigation and may lead to a better understanding of cariogenesis in diverse populations, and help to improve dental caries prediction, prevention, and/or treatment in future.

Dataset Information

The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.

Publications

The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.

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