G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria.

ABSTRACT:

Background

Host genetic factors contribute to the variability of malaria phenotypes and can allow a better understanding of mechanisms involved in susceptibility and/or resistance to Plasmodium falciparum infection outcomes. Several genetic polymorphisms were reported to be prevalent among populations living in tropical malaria-endemic regions and induce protection against malaria. The present study aims to investigate the prevalence of HBB (chr11) and G6PD (chrX) deficiencies polymorphisms among Senegalese populations and their associations with the risk for severe Plasmodium falciparum malaria occurrence.

Methods

We performed a retrospective study with 437 samples, 323 patients recruited in hospitals located in three different endemic areas wher

SUBMITTER: Thiam F 

PROVIDER: S-EPMC9266585 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature