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Centipede Venom: A Potential Source of Ion Channel Modulators.

ABSTRACT: Centipedes are one of the most ancient and successful living venomous animals. They have evolved spooky venoms to deter predators or hunt prey, and are widely distributed throughout the world besides Antarctica. Neurotoxins are the most important virulence factor affecting the function of the nervous system. Ion channels and receptors expressed in the nervous system, including Na_V, K_V, Ca_V, and TRP families, are the major targets of peptide neurotoxins. Insight into the mechanism of neurotoxins acting on ion channels contributes to our understanding of the function of both channels and centipede venoms. Meanwhile, the novel structure and selective activities give them the enormous potential to be modified and exploited as research tools and biological drugs. Here, we review the centipede venom peptides that act on ion channels.

SUBMITTER: Luo A

PROVIDER: S-EPMC9266919 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Centipede Venom: A Potential Source of Ion Channel Modulators.

Luo Anna A Wang Aili A Kamau Peter Muiruri PM Lai Ren R Luo Lei L

International journal of molecular sciences 20220626 13

Centipedes are one of the most ancient and successful living venomous animals. They have evolved spooky venoms to deter predators or hunt prey, and are widely distributed throughout the world besides Antarctica. Neurotoxins are the most important virulence factor affecting the function of the nervous system. Ion channels and receptors expressed in the nervous system, including NaV, KV, CaV, and TRP families, are the major targets of peptide neurotoxins. Insight i ...[more]

PMID: 35806107

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