Ontology highlight
ABSTRACT:
SUBMITTER: Khalid M
PROVIDER: S-EPMC9267661 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Khalid Mohammad M Alqarni Mohammed H MH Wahab Shadma S Annadurai Sivakumar S Alamri Mubarak A MA Foudah Ahmed I AI Aljarba Tariq M TM Akhtar Juber J Badruddeen Ahmad Sarfaraz S
Journal of clinical medicine 20220628 13
The ethanolic extracts of Spondias mangifera fruit (SMFE) were evaluated for aphrodisiac activity. The in-vitro phosphodiesterase-5 (PDE-5) inhibition was assessed based on in-silico molecular docking and simulation studies. In addition, the in-vivo sexual behavior was analyzed in the form of mount (MF, ML), intromission (IF, IL), and ejaculation (EF, EL) frequencies and latencies to validate the in-vitro results. Some biochemical parameters, including PDE-5, nitric oxide, and testosterone, were ...[more]