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Ameliorative Sexual Behavior and Phosphodiesterase-5 Inhibitory Effects of Spondias mangifera Fruit Extract in Rodents: In Silico, In Vitro, and In Vivo Study.


ABSTRACT: The ethanolic extracts of Spondias mangifera fruit (SMFE) were evaluated for aphrodisiac activity. The in-vitro phosphodiesterase-5 (PDE-5) inhibition was assessed based on in-silico molecular docking and simulation studies. In addition, the in-vivo sexual behavior was analyzed in the form of mount (MF, ML), intromission (IF, IL), and ejaculation (EF, EL) frequencies and latencies to validate the in-vitro results. Some biochemical parameters, including PDE-5, nitric oxide, and testosterone, were also observed. The above extract constituted β-amyrin, β-sitosterol, and oleanolic acid and showed tremendous binding with phosphodiesterase-5 and sildenafil. Both the sildenafil and ethanolic extracts (200 and 400 mg/kg/d bodyweight) significantly (p < 0.1, p < 0.05) increased MF, IF, and EF, respectively. In contrast, ML and IL significantly (p < 0.1) decreased, and EL significantly (p < 0.1) increased compared with a normal group of animals. The ethanolic extracts (200 and 400 mg/kg/d bodyweight) and sildenafil further significantly (p < 0.05, p < 0.1) diminished PDE-5 activity significantly (p < 0.05, p < 0.1) and enhanced nitric oxide and testosterone levels, as compared with normal rodents. Therefore, the S. mangifera ethanolic extract might be a valuable alternate aphrodisiac for erectile dysfunction.

SUBMITTER: Khalid M 

PROVIDER: S-EPMC9267661 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Ameliorative Sexual Behavior and Phosphodiesterase-5 Inhibitory Effects of <i>Spondias mangifera</i> Fruit Extract in Rodents: <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Study.

Khalid Mohammad M   Alqarni Mohammed H MH   Wahab Shadma S   Annadurai Sivakumar S   Alamri Mubarak A MA   Foudah Ahmed I AI   Aljarba Tariq M TM   Akhtar Juber J   Badruddeen   Ahmad Sarfaraz S  

Journal of clinical medicine 20220628 13


The ethanolic extracts of Spondias mangifera fruit (SMFE) were evaluated for aphrodisiac activity. The in-vitro phosphodiesterase-5 (PDE-5) inhibition was assessed based on in-silico molecular docking and simulation studies. In addition, the in-vivo sexual behavior was analyzed in the form of mount (MF, ML), intromission (IF, IL), and ejaculation (EF, EL) frequencies and latencies to validate the in-vitro results. Some biochemical parameters, including PDE-5, nitric oxide, and testosterone, were  ...[more]

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2020-12-01 | GSE142427 | GEO
2017-02-09 | GSE78733 | GEO