Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis.

ABSTRACT:

Background

Natural killer T (NKT) cells are unconventional T cells that bridge innate and adaptive immunity. NKT cells have been implicated in the development of atopic dermatitis (AD).

Objective

We aimed to investigate the role of NKT cells in AD development, especially in skin.

Methods

Global proteomic and transcriptomic analyses were performed by using skin and blood from human healthy-controls and patients with AD. Levels of CXCR4 and CXCL12 expression in skin NKT cells were analyzed in human AD and mouse AD models. By using parabiosis and intravital imaging, the role of skin CXCR4⁺ NKT cells was further evaluated in models of mice with AD by using CXCR4-conditionally deficient or CXCL12 transgenic mice.

Results

CXCR4 and its cognate ligand CXCL1

SUBMITTER: Sun Z 

PROVIDER: S-EPMC9272812 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature