Effects of PEEP on regional ventilation-perfusion mismatch in the acute respiratory distress syndrome.

ABSTRACT:

Purpose

In the acute respiratory distress syndrome (ARDS), decreasing Ventilation-Perfusion [Formula: see text] mismatch might enhance lung protection. We investigated the regional effects of higher Positive End Expiratory Pressure (PEEP) on [Formula: see text] mismatch and their correlation with recruitability. We aimed to verify whether PEEP improves regional [Formula: see text] mismatch, and to study the underlying mechanisms.

Methods

In fifteen patients with moderate and severe ARDS, two PEEP levels (5 and 15 cmH₂O) were applied in random order. [Formula: see text] mismatch was assessed by Electrical Impedance Tomography at each PEEP. Percentage of ventilation and perfusion reaching different ranges of [Formula: see text] ratios were analyzed in 3 gravitationa

SUBMITTER: Pavlovsky B 

PROVIDER: S-EPMC9272883 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature