Virus reactivation in a non-cirrhotic HBV patient requiring liver transplantation after cessation of nucleoside analogue therapy.
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ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC9272995 | biostudies-literature | 2021 Jan-Feb
REPOSITORIES: biostudies-literature
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Virus reactivation in a non-cirrhotic HBV patient requiring liver transplantation after cessation of nucleoside analogue therapy.
Zhang Han H Chen Fang F Giang Erick E Bao Fei F Lauer Georg M GM Marsh Christopher C Law Mansun M Pockros Paul J PJ
Antiviral therapy 20210101 1-2
Nucleos(t)ide analogues (NAs) are a mainstay of therapy for chronic hepatitis B (CHB) infections and have a profound effect on hepatitis B virus (HBV) suppression. We report a rare case of HBV reactivation in a CHB patient without cirrhosis following cessation of NA therapy that resulted in acute liver failure requiring liver transplantation. Investigation of the viral genetics and host immune responses suggest that viral mutations known to promote virus replication are associated with reactivat ...[more]
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