Clinical Images: Giant mass on the forehead in Kimura disease.
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ABSTRACT:
SUBMITTER: Yoshida T
PROVIDER: S-EPMC9274332 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Kimura disease presents as benign lesion and is commonly present among the Asian population. It is a disease with a favourable prognosis and a peak age of onset in the third decade. It is a chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissues of the head and neck region. We report a case of a 15-year-old boy with multiple Kimura lymphadenopathies involving the left posterior auricular region as well as the anterior and posterior triangles of the neck.
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Project description:Dr. Hideo Kimura is recognized as a redox pioneer because he has published an article in the field of antioxidant and redox biology that has been cited >1000 times, and 29 articles that have been cited >100 times. Since the first description of hydrogen sulfide (H2S) as a toxic gas 300 years ago, most studies have been devoted to its toxicity. In 1996, Dr. Kimura demonstrated a physiological role of H2S as a mediator of cognitive function and cystathionine β-synthase as an H2S-producing enzyme. In the following year, he showed H2S as a vascular smooth muscle relaxant in synergy with nitric oxide and its production by cystathionine γ-lyase in vasculature. Subsequently he reported the cytoprotective effect of H2S on neurons against oxidative stress. Since then, studies on H2S have unveiled numerous physiological roles such as the regulation of inflammation, cell growth, oxygen sensing, and senescence. He also discovered polysulfides (H2Sn), which have a higher number of sulfur atoms than H2S and are one of the active forms of H2S, as potent signaling molecules produced by 3-mercaptopyruvate sulfurtransferase. H2Sn regulate ion channels and transcription factors to upregulate antioxidant genes, tumor suppressors, and protein kinases to, in turn, regulate blood pressure. These findings led to the re-evaluation of other persulfurated molecules such as cysteine persulfide and glutathione persulfide. Dr. Kimura is a pioneer of studies on H2S and H2Sn as signaling molecules. It is fortunate to come across a secret of nature and pick it up. -Prof. Hideo Kimura.
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