Dataset Information

Relaxation-weighted ²³Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis.

ABSTRACT:

Objectives

Multiparametric magnetic resonance imaging (MRI) is established as a technical instrument for the characterisation of patients with amyotrophic lateral sclerosis (ALS). The contribution of relaxation-weighted sodium (²³NaR) MRI remains to be defined. The aim of this study is to apply ²³NaR MRI to investigate brain sodium homeostasis and map potential alterations in patients with ALS as compared with healthy controls.

Materials and methods

Seventeen patients with ALS (mean age 61.1 ± 11.4 years, m/f = 9/8) and 10 healthy control subjects (mean age 60.3 ± 15.3 years, m/f = 6/4) were examined by ²³NaR MRI at 3 T. Regional sodium maps were obtained by the calculation of the weighted difference from two image data sets with different echo times (TE₁ = 0.3 ms, TE₂ = 25 ms). Voxel-based analysis of the relaxation-weighted maps, together with ²³Na concentration maps for comparison, was performed.

Results

ROI-based analyses of relaxation-weighted brain sodium concentration maps demonstrated increased sodium concentrations in the upper corticospinal tracts and in the frontal lobes in patients with ALS; no differences between ALS patients and controls were found in reference ROIs, where no involvement in ALS-associated neurodegeneration could be anticipated.

Conclusion

²³NaR MRI mapped regional alterations within disease-relevant areas in ALS which correspond to the stages of the central nervous system (CNS) pathology, providing evidence that the technique is a potential biological marker of the cerebral neurodegenerative process in ALS.

SUBMITTER: Muller HP

PROVIDER: S-EPMC9274400 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Dataset Information

Relaxation-weighted ²³Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis.

Objectives

Materials and methods

Results

Conclusion

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OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Relaxation-weighted 23Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis.

Objectives

Materials and methods

Results

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OmicsDI is part of the ELIXIR infrastructure

Tweets

Relaxation-weighted ²³Na magnetic resonance imaging maps regional patterns of abnormal sodium concentrations in amyotrophic lateral sclerosis.