Different phylotypes of Cutibacterium acnes cause different modic changes in intervertebral disc degeneration.

ABSTRACT:

Background

The contribution of Cutibacterium acnes (C. acnes) infection to intervertebral disc degeneration (IDD) and the antibiotic therapy has evoked several controversies in recent years. While some microbiology studies report bacterial disc infection within IDD patients, others attribute the positive results to contamination during prolonged cultures. In addition to the clinical controversy, little was known about the mechanism of C. acnes-caused Modic changes (MCs) if C. acnes was the pathogenic factor.

Objectives

This study aimed to investigate the inflammatory mechanism of MCs induced by different phylotypes of C. acnes in patients with IDD.

Methods

Specimens from sixty patients undergoing microdiscectomy for disc herniation were included, C. acnes were identif

SUBMITTER: Lan W 

PROVIDER: S-EPMC9275720 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature