Total circulating microRNA level as an independent prognostic marker for risk stratification in breast cancer.

ABSTRACT:

Background

Although breast cancer (BC) has a high survival rate, relapse events may occur which ultimately lead to aggressive disease. Circulating cell-free microRNAs (cf-miRNAs) are a promising minimally invasive biomarker with diagnostic and/or prognostic potential. Unfortunately, there is still no consensus as to a universal cf-miRNA biomarker in BC and there has been no clinical implementation until now. One major limitation is the technical variation with cf-miRNA isolation and specific quantification methods.

Methods

In this study, we assessed the total levels of cf-miRNAs as a potential prognostic marker for BC in 356 plasma samples from 250 BC patients.

Results

High levels of cf-miRNAs significantly correlated with unfavourable clinical features including tumo

SUBMITTER: Gahlawat AW 

PROVIDER: S-EPMC9276748 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature