Ontology highlight
ABSTRACT:
SUBMITTER: Guslund NC
PROVIDER: S-EPMC9276791 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Guslund Naomi Croft NC Krabberød Anders K AK Nørstebø Simen F SF Solbakken Monica Hongrø MH Jakobsen Kjetill S KS Johansen Finn-Eirik FE Qiao Shuo-Wang SW
Communications biology 20220711 1
Atlantic Cod (Gadus morhua) has lost the major histocompatibility complex class II presentation pathway. We recently identified CD8-positive T cells, B cells, and plasma cells in cod, but further characterisation of lymphocyte subsets is needed to elucidate immune adaptations triggered by the absence of CD4-positive T lymphocytes. Here, we use single-cell RNA sequencing to examine the lymphocyte heterogeneity in Atlantic cod spleen. We describe five T cell subsets and eight B cell subsets and pr ...[more]