Artificial Intelligence Can’t Be Charmed: The Effects of Impartiality on Laypeople’s Algorithmic Preferences
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ABSTRACT:
SUBMITTER: Claudy M
PROVIDER: S-EPMC9277554 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:In healthcare, the development and deployment of insufficiently fair systems of artificial intelligence (AI) can undermine the delivery of equitable care. Assessments of AI models stratified across subpopulations have revealed inequalities in how patients are diagnosed, treated and billed. In this Perspective, we outline fairness in machine learning through the lens of healthcare, and discuss how algorithmic biases (in data acquisition, genetic variation and intra-observer labelling variability, in particular) arise in clinical workflows and the resulting healthcare disparities. We also review emerging technology for mitigating biases via disentanglement, federated learning and model explainability, and their role in the development of AI-based software as a medical device.
| S-EPMC10632090 | biostudies-literature
Project description:BackgroundArtificial intelligence (AI) is increasingly being proposed for use in medicine, including breast cancer screening (BCS). Little is known, however, about referring primary care providers' (PCPs') preferences for this technology.MethodsWe identified the most important attributes of AI BCS for ordering PCPs using qualitative interviews: sensitivity, specificity, radiologist involvement, understandability of AI decision-making, supporting evidence, and diversity of training data. We invited US-based PCPs to participate in an internet-based experiment designed to force participants to trade off among the attributes of hypothetical AI BCS products. Responses were analyzed with random parameters logit and latent class models to assess how different attributes affect the choice to recommend AI-enhanced screening.ResultsNinety-one PCPs participated. Sensitivity was most important, and most PCPs viewed radiologist participation in mammography interpretation as important. Other important attributes were specificity, understandability of AI decision-making, and diversity of data. We identified 3 classes of respondents: "Sensitivity First" (41%) found sensitivity to be more than twice as important as other attributes; "Against AI Autonomy" (24%) wanted radiologists to confirm every image; "Uncertain Trade-Offs" (35%) viewed most attributes as having similar importance. A majority (76%) accepted the use of AI in a "triage" role that would allow it to filter out likely negatives without radiologist confirmation.Conclusions and relevanceSensitivity was the most important attribute overall, but other key attributes should be addressed to produce clinically acceptable products. We also found that most PCPs accept the use of AI to make determinations about likely negative mammograms without radiologist confirmation.
| S-EPMC8200265 | biostudies-literature
Project description:BackgroundArtificial intelligence (AI) has shown potential to improve diagnostics of various diseases, especially for early detection of skin cancer. Studies have yet to investigate the clear application of AI technology in clinical practice or determine the added value for younger user groups. Translation of AI-based diagnostic tools can only be successful if they are accepted by potential users. Young adults as digital natives may offer the greatest potential for successful implementation of AI into clinical practice, while at the same time, representing the future generation of skin cancer screening participants.ObjectiveWe conducted an anonymous online survey to examine how and to what extent individuals are willing to accept AI-based mobile apps for skin cancer diagnostics. We evaluated preferences and relative influences of concerns, with a focus on younger age groups.MethodsWe recruited participants below 35 years of age using three social media channels-Facebook, LinkedIn, and Xing. Descriptive analysis and statistical tests were performed to evaluate participants' attitudes toward mobile apps for skin examination. We integrated an adaptive choice-based conjoint to assess participants' preferences. We evaluated potential concerns using maximum difference scaling.ResultsWe included 728 participants in the analysis. The majority of participants (66.5%, 484/728; 95% CI 0.631-0.699) expressed a positive attitude toward the use of AI-based apps. In particular, participants residing in big cities or small towns (P=.02) and individuals that were familiar with the use of health or fitness apps (P=.02) were significantly more open to mobile diagnostic systems. Hierarchical Bayes estimation of the preferences of participants with a positive attitude (n=484) revealed that the use of mobile apps as an assistance system was preferred. Participants ruled out app versions with an accuracy of ≤65%, apps using data storage without encryption, and systems that did not provide background information about the decision-making process. However, participants did not mind their data being used anonymously for research purposes, nor did they object to the inclusion of clinical patient information in the decision-making process. Maximum difference scaling analysis for the negative-minded participant group (n=244) showed that data security, insufficient trust in the app, and lack of personal interaction represented the dominant concerns with respect to app use.ConclusionsThe majority of potential future users below 35 years of age were ready to accept AI-based diagnostic solutions for early detection of skin cancer. However, for translation into clinical practice, the participants' demands for increased transparency and explainability of AI-based tools seem to be critical. Altogether, digital natives between 18 and 24 years and between 25 and 34 years of age expressed similar preferences and concerns when compared both to each other and to results obtained by previous studies that included other age groups.
| S-EPMC8433862 | biostudies-literature
Project description:We propose a model of a learning agent whose interaction with the environment is governed by a simulation-based projection, which allows the agent to project itself into future situations before it takes real action. Projective simulation is based on a random walk through a network of clips, which are elementary patches of episodic memory. The network of clips changes dynamically, both due to new perceptual input and due to certain compositional principles of the simulation process. During simulation, the clips are screened for specific features which trigger factual action of the agent. The scheme is different from other, computational, notions of simulation, and it provides a new element in an embodied cognitive science approach to intelligent action and learning. Our model provides a natural route for generalization to quantum-mechanical operation and connects the fields of reinforcement learning and quantum computation.
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Project description:ObjectivesTest whether (1) people view a policing decision made by an algorithm as more or less trustworthy than when an officer makes the same decision; (2) people who are presented with a specific instance of algorithmic policing have greater or lesser support for the general use of algorithmic policing in general; and (3) people use trust as a heuristic through which to make sense of an unfamiliar technology like algorithmic policing.MethodsAn online experiment tested whether different decision-making methods, outcomes and scenario types affect judgements about the appropriateness and fairness of decision-making and the general acceptability of police use of this particular technology.ResultsPeople see a decision as less fair and less appropriate when an algorithm decides, compared to when an officer decides. Yet, perceptions of fairness and appropriateness were strong predictors of support for police use of algorithms, and being exposed to a successful use of an algorithm was linked, via trust in the decision made, to greater support for police use of algorithms.ConclusionsMaking decisions solely based on algorithms might damage trust, and the more police rely solely on algorithmic decision-making, the less trusting people may be in decisions. However, mere exposure to the successful use of algorithms seems to enhance the general acceptability of this technology.Supplementary informationThe online version contains supplementary material available at 10.1007/s11292-021-09484-9.
| S-EPMC8435155 | biostudies-literature
Project description:Swarm systems are based on intermediate connectivity between individuals and dynamic neighborhoods. In natural swarms self-organizing principles bring their agents to that favorable level of connectivity. They serve as interesting sources of inspiration for control algorithms in swarm robotics on the one hand, and in modular robotics on the other hand. In this paper we demonstrate and compare a set of bio-inspired algorithms that are used to control the collective behavior of swarms and modular systems: BEECLUST, AHHS (hormone controllers), FGRN (fractal genetic regulatory networks), and VE (virtual embryogenesis). We demonstrate how such bio-inspired control paradigms bring their host systems to a level of intermediate connectivity, what delivers sufficient robustness to these systems for collective decentralized control. In parallel, these algorithms allow sufficient volatility of shared information within these systems to help preventing local optima and deadlock situations, this way keeping those systems flexible and adaptive in dynamic non-deterministic environments.
| S-EPMC3688318 | biostudies-literature
Project description:Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) plays a pivotal role in preventing autoimmunity and fostering anticancer immunity by interacting with B7 proteins CD80 and CD86. CTLA-4 is the first immune checkpoint targeted with a monoclonal antibody inhibitor. Checkpoint inhibitors have generated durable responses in many cancer patients, representing a revolutionary milestone in cancer immunotherapy. However, therapeutic efficacy is limited to a small portion of patients, and immune-related adverse events are noteworthy, especially for monoclonal antibodies directed against CTLA-4. Previously, small molecules have been developed to impair the CTLA-4: CD80 interaction; however, they directly targeted CD80 and not CTLA-4. In this study, we performed artificial intelligence (AI)-powered virtual screening of approximately ten million compounds to target CTLA-4. We validated primary hits with biochemical, biophysical, immunological, and experimental animal assays. We then optimized lead compounds and obtained inhibitors with an inhibitory concentration of 1 micromole in disrupting the interaction between CTLA-4 and CD80. Unlike ipilimumab, these small molecules did not degrade CTLA-4. Several compounds inhibited tumor development prophylactically and therapeutically in syngeneic and CTLA-4-humanized mice. This project supports an AI-based framework in designing small molecules targeting immune checkpoints for cancer therapy.
2024-02-15 | GSE228560 | GEO
Project description:Algorithms provide recommendations to human decision makers across a variety of task domains. For many problems, humans will rely on algorithmic advice to make their choices and at times will even show complacency. In other cases, humans are mistrustful of algorithmic advice, or will hold algorithms to higher standards of performance. Given the increasing use of algorithms to support creative work such as text generation and brainstorming, it is important to understand how humans will respond to algorithms in those scenarios-will they show appreciation or aversion? This study tests the effects of algorithmic advice for a word association task, the remote associates test (RAT). The RAT task is an established instrument for testing critical and creative thinking with respect to multiple word association. We conducted a preregistered online experiment (154 participants, 2772 observations) to investigate whether humans had stronger reactions to algorithmic or crowd advice when completing multiple instances of the RAT. We used an experimental format in which subjects see a question, answer the question, then receive advice and answer the question a second time. Advice was provided in multiple formats, with advice varying in quality and questions varying in difficulty. We found that individuals receiving algorithmic advice changed their responses 13[Formula: see text] more frequently ([Formula: see text], [Formula: see text]) and reported greater confidence in their final solutions. However, individuals receiving algorithmic advice also were 13[Formula: see text] less likely to identify the correct solution ([Formula: see text], [Formula: see text]). This study highlights both the promises and pitfalls of leveraging algorithms to support creative work.
| S-EPMC9411628 | biostudies-literature
Project description:BackgroundThe aim of this study was to assess social preferences for two different advanced digital health technologies and investigate the contextual dependency of the preferences.MethodsA cross-sectional online survey was performed among the general population of Hungary aged 40 years and over. Participants were asked to imagine that they needed a total hip replacement surgery and to indicate whether they would prefer a traditional or a robot-assisted (RA) hip surgery. To better understand preferences for the chosen method, the willingness to pay (WTP) method was used. The same assessment was conducted for preferences between a radiologist's and AI-based image analysis in establishing the radiological diagnosis of a suspected tumour. Respondents' electronic health literacy was assessed with the eHEALS questionnaire. Descriptive methods were used to assess sample characteristics and differences between subgroups. Associations were investigated with correlation analysis and multiple linear regressions.ResultsAltogether, 1400 individuals (53.7% female) with a mean age of 58.3 (SD = 11.1) years filled in the survey. RA hip surgery was chosen by 762 (54.4%) respondents, but only 470 (33.6%) chose AI-based medical image evaluation. Those who opted for the digital technology had significantly higher educational levels and electronic health literacy (eHEALS). The majority of respondents were willing to pay to secure their preferred surgical (surgeon 67.2%, robot-assisted: 68.8%) and image assessment (radiologist: 70.9%; AI: 77.4%) methods, reporting similar average amounts in the first (p = 0.677), and a significantly higher average amount for radiologist vs. AI in the second task (p = 0.001). The regression showed a significant association between WTP and income, and in the hip surgery task, it also revealed an association with the type of intervention chosen.ConclusionsIndividuals with higher education levels seem to accept the advanced digital medical technologies more. However, the greater openness for RA surgery than for AI image assessment highlights that social preferences may depend considerably on the medical situation and the type of advanced digital technology. WTP results suggest rather firm preferences in the great majority of the cases. Determinants of preferences and real-world choices of affected patients should be further investigated in future studies.
| S-EPMC10981282 | biostudies-literature
Project description:The interest in artificial intelligence (AI) has ballooned within radiology in the past few years primarily due to notable successes of deep learning. With the advances brought by deep learning, AI has the potential to recognize and localize complex patterns from different radiological imaging modalities, many of which even achieve comparable performance to human decision-making in recent applications. In this chapter, we review several AI applications in radiology for different anatomies: chest, abdomen, pelvis, as well as general lesion detection/identification that is not limited to specific anatomies. For each anatomy site, we focus on introducing the tasks of detection, segmentation, and classification with an emphasis on describing the technology development pathway with the aim of providing the reader with an understanding of what AI can do in radiology and what still needs to be done for AI to better fit in radiology. Combining with our own research experience of AI in medicine, we elaborate how AI can enrich knowledge discovery, understanding, and decision-making in radiology, rather than replacing the radiologist.
| S-EPMC7484814 | biostudies-literature