Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.

ABSTRACT:

Background

Despite the prevalence of motor symptoms in mild cognitive impairment (MCI) and Alzheimer's disease (AD), their underlying neural mechanisms have not been thoroughly studied.

Objective

This review summarizes the neural underpinnings of motor deficits in MCI and AD.

Methods

We searched PubMed up until August of 2021 and identified 37 articles on neuroimaging of motor function in MCI and AD. Study bias was evaluated based on sample size, availability of control samples, and definition of the study population in terms of diagnosis.

Results

The majority of studies investigated gait, showing that slower gait was associated with smaller hippocampal volume and prefrontal deactivation. Less prefrontal activation was also observed during cognitive-motor dual

SUBMITTER: Koppelmans V 

PROVIDER: S-EPMC9277676 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature