Associations of visceral adipose tissue with bone mineral density and fracture: observational and Mendelian randomization studies.

ABSTRACT:

Background

The associations between visceral adipose tissue (VAT) and bone mineral density (BMD) or fracture have been controversial and the causality of the associations remains to be assessed. This study aimed to explore the associations of VAT^ (predicted value of VAT mass) with BMD and fracture risk in men and women, and to examine their potential causation by two-sample Mendelian randomization (MR) analyses.

Methods

UK Biobank is a large, population-based prospective cohort study that recruited more than 500,000 participants aged 40-69 in the United Kingdom from 2006 to 2010. In this study, we used a validated and reliable prediction model to estimate the VAT amount of the participants. On this basis, linear and nonlinear multivariable statistical models were used to ex

SUBMITTER: Hu J 

PROVIDER: S-EPMC9277855 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature