Dataset Information

MRNA (BNT162b2) COVID-19 vaccination increased risk of Bell's palsy: a nested case control and self-controlled case series study.

ABSTRACT:

Background

Observable symptoms of Bell's palsy following vaccinations may arouse concern over the safety profiles of novel COVID-19 vaccines in the general public. However, there are only a few studies on Bell's palsy following mRNA COVID-19 vaccination with inconclusive findings. This study aimed to update the previous analysis on the risk of Bell's palsy following mRNA (BNT162b2) COVID-19 vaccination.

Methods

This study included cases aged ≥16-years-old with a new diagnosis of Bell's palsy within 28 days after BNT162b2 vaccinations from the population-based electronic health records in Hong Kong, using a nested case-control and self-controlled case series (SCCS) analyses were employed. The association between Bell's palsy and BNT162b2 was evaluated using conditional logistic and Poisson regression in nested case-control and SCCS analysis, respectively.

Results

A total of 54 individuals were newly diagnosed with Bell's palsy after BNT162b2 vaccinations. The incidence of Bell's palsy was 1.58 (95% CI:1.19-2.07) per 100,000 doses administered. The nested case-control analysis showed significant association between BNT162b2 vaccinations and Bell's palsy (Adjusted OR: 1.543, 95%CI:1.123 - 2.121), with up to 1.112 excess events per 100,000 people receiving two doses of BNT162b2. An increased risk of Bell's palsy was observed during the first 14 days after the second dose of BNT162b2 in both nested case-control (Adjusted OR: 2.325, 95%CI:1.414 - 3.821) and SCCS analysis (Adjusted IRR=2.44, 95%CI:1.32-4.50).

Conclusion

There is an overall increased risk of Bell's palsy following BNT162b2 vaccination, particularly within the first 14 days after the second dose, but the absolute risk was very low.

SUBMITTER: Wan EYF

PROVIDER: S-EPMC9278169 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination With BNT162b2 Increased Risk of Bell's Palsy: A Nested Case-Control and Self-Controlled Case Series Study.

Wan Eric Yuk Fai EYF Chui Celine Sze Ling CSL Ng Vanessa Wai Sei VWS Wang Yuan Y Yan Vincent Ka Chun VKC Lam Ivan Chun Hang ICH Fan Min M Lai Francisco Tsz Tsun FTT Chan Esther Wai Yin EWY Li Xue X Wong Carlos King Ho CKH Chung Raccoon Ka Cheong RKC Cowling Benjamin John BJ Fong Wing Chi WC Lau Alexander Yuk Lun AYL Mok Vincent Chung Tong VCT Chan Frank Ling Fung FLF Lee Cheuk Kwong CK Chan Lot Sze Tao LST Lo Dawin D Lau Kui Kai KK Hung Ivan Fan Ngai IFN Lau Chak Sing CS Leung Gabriel Matthew GM Wong Ian Chi Kei ICK

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20230201 3

<h4>Background</h4>Observable symptoms of Bell's palsy following vaccinations arouse concern over the safety profiles of novel coronavirus disease 2019 (COVID-19) vaccines. However, there are only inconclusive findings on Bell's palsy following messenger (mRNA) COVID-19 vaccination. This study aims to update the previous analyses on the risk of Bell's palsy following mRNA (BNT162b2) COVID-19 vaccination.<h4>Methods</h4>This study included cases aged ≥16 years with a new diagnosis of Bell's palsy ...[more]

PMID: 35675702

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