Dataset Information

Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity.

ABSTRACT:

Background

Immunization of vulnerable populations with distinct immunity often results in suboptimal immunogenicity, durability, and efficacy.

Methods

Safety and immunogenicity profiles of BNT162b2 messenger RNA coronavirus disease 2019 (COVID-19) vaccine, among people living with human immunodeficiency virus (HIV), were evaluated in 28 perinatally HIV-infected patients under antiretroviral therapy (ART) and 65 healthy controls (HCs) with no previous history of COVID-19. Thus, we measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific humoral and CD4+ T cell responses. Samples were collected before vaccination (baseline, day [D] 0), at the second dose (D21), and at 4 weeks (D28) and 6 months (D180) after D0. Proteomic profiles at D0 and D28 were assessed with a multiplexed proximity extension assay (Olink) on plasma samples.

Results

All HIV-infected patients mounted similar anti-SARS-CoV-2 humoral responses to those of HCs, albeit with lower titers of anti-trimeric S at D28 (P = .01). Only peripheral blood mononuclear cells of HIV-infected patients demonstrated at D28 an impaired ability to expand their specific (CD40L+) CD4+ T-cell populations. Similar humoral titers were maintained between the 2 groups at 6-months follow-up. We additionally correlated baseline protein levels to either humoral or cellular responses, identifying clusters of molecules involved in immune response regulation with inverse profiles between the 2 study groups.

Conclusions

Responses of ART-treated HIV-infected patients, compared to those of HCs, were characterized by distinct features especially within the proteomic compartment, supporting their eligibility to an additional dose, similarly to the HC schedule.

SUBMITTER: Morrocchi E

PROVIDER: S-EPMC9278233 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity.

Morrocchi Elena E Pighi Chiara C Pascucci Giuseppe Rubens GR Cotugno Nicola N Medri Chiara C Amodio Donato D Colagrossi Luna L Ruggiero Alessandra A Manno Emma Concetta EC Casamento Tumeo Chiara C Bernardi Stefania S Smolen Kinga K KK Perno Carlo Federico CF Ozonoff Al A Rossi Paolo P Levy Ofer O Palma Paolo P

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20220801 Suppl 1

<h4>Background</h4>Immunization of vulnerable populations with distinct immunity often results in suboptimal immunogenicity, durability, and efficacy.<h4>Methods</h4>Safety and immunogenicity profiles of BNT162b2 messenger RNA coronavirus disease 2019 (COVID-19) vaccine, among people living with human immunodeficiency virus (HIV), were evaluated in 28 perinatally HIV-infected patients under antiretroviral therapy (ART) and 65 healthy controls (HCs) with no previous history of COVID-19. Thus, we ...[more]

PMID: 35738253

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Dataset Information

Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity.

Background

Methods

Results

Conclusions

Publications

Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity.

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