Force Transmission in Disordered Fibre Networks.

ABSTRACT: Cells residing in living tissues apply forces to their immediate surroundings to promote the restructuration of the extracellular matrix fibres and to transmit mechanical signals to other cells. Here we use a minimalist model to study how these forces, applied locally by cell contraction, propagate through the fibrous network in the extracellular matrix. In particular, we characterize how the transmission of forces is influenced by the connectivity of the network and by the bending rigidity of the fibers. For highly connected fiber networks the stresses spread out isotropically around the cell over a distance that first increases with increasing contraction of the cell and then saturates at a characteristic length. For lower connectivity, however, the stress pattern is highly asymmetric an

SUBMITTER: Ruiz-Franco J 

PROVIDER: S-EPMC9280074 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature