Intracellular K⁺-Responsive Block Copolymer Micelles for Targeted Drug Delivery of Curcumin.

ABSTRACT: Curcumin (CUR) is a natural bioactive compound that has attracted attention as a "golden molecule" due to its therapeutic properties against several types of tumors. Nonetheless, the antitumor application of CUR is hampered due to its extremely low aqueous solubility and chemical instability. Herein, a novel type of CUR-loaded polymeric micelles with intracellular K⁺-responsive controlled-release properties is designed and developed. The polymeric micelles are self-assembled by poly (N-isopropylacrylamide-co-acryloylamidobenzo-15-crown-5-co-N, N-dimethylacrylamide)-b-DSPE (PNDB-b-DSPE) block copolymers, and CUR. CUR is successfully loaded into the micelles with a CUR loading content of 6.26 wt%. The proposed CUR-PNDB-DSPE polymeric micelles exh

SUBMITTER: Jiang M 

PROVIDER: S-EPMC9280407 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature