Oxidation-Responsive, Tunable Growth Factor Delivery from Polyelectrolyte-Coated Implants.

ABSTRACT: Polyelectrolyte multilayer (PEM) coatings, constructed on the surfaces of tissue engineering scaffolds using layer-by-layer assembly (LbL), promote sustained release of therapeutic molecules and have enabled regeneration of large-scale, pre-clinical bone defects. However, these systems primarily rely on non-specific hydrolysis of PEM components to foster drug release, and their pre-determined drug delivery schedules potentially limit future translation into innately heterogeneous patient populations. To trigger therapeutic delivery directly in response to local environmental stimuli, an LbL-compatible polycation solely degraded by cell-generated reactive oxygen species (ROS) was synthesized. These thioketal-based polymers were selectively cleaved by physiologic doses of ROS, stably incorpo

SUBMITTER: Martin JR 

PROVIDER: S-EPMC9280659 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature