Rotator Cuff Tear Size Regulates Fibroadipogenic Progenitor Number and Gene Expression Profile in the Supraspinatus Independent of Patient Age.

ABSTRACT:

Background

Fatty infiltration of rotator cuff muscle is a limiting factor in the success of repairs. Fibroadipogenic progenitors (FAPs) are a population of stem cells within the rotator cuff that can differentiate into white adipocytes, fibroblasts, and beige adipocytes. The effects of patient age and rotator cuff tendon tear size on the number, differentiation patterns, and gene expression profiles of FAPs have not yet been analyzed.

Purpose

To determine if patient age and rotator cuff tear size independently regulate FAP number, differentiation patterns, and gene expression profiles.

Study design

Controlled laboratory study.

Methods

Supraspinatus muscle samples were collected from 26 patients between the ages of 42 and 76 years with partial- or full-thickness

SUBMITTER: Davies MR 

PROVIDER: S-EPMC9280916 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature