Predictors of mortality among inpatients with COVID-19 infection in a tertiary referral center in the Philippines.

ABSTRACT:

Objectives

The aim of this study was to determine the predictors of mortality and describe laboratory trends among adults with confirmed COVID-19.

Methods

The medical records of adult patients admitted to a referral hospital with COVID-19 were retrospectively reviewed. Demographic and clinical characteristics, and laboratory parameters, were compared between survivors and non-survivors. Predictors of mortality were determined by multivariate analysis. Mean laboratory values were plotted across illness duration.

Results

Of 1215 patients, 203 (16.7%) had mild, 488 (40.2%) moderate, 183 (15.1%) severe, and 341 (28.1%) critical COVID-19 on admission. In-hospital mortality was 18.2% (0% mild, 6.1% moderate, 15.8% severe, 47.5% critical). Predictors of mortality were age ≥ 60 years, COPD, qSOFA score ≥ 2, WBC > 10 × 10⁹/L, absolute lymphocyte count < 1000, neutrophil ≥ 70%, PaO₂/FiO₂ ratio ≤ 200, eGFR < 90 mL/min/1.73 m², LDH > 600 U/L, and CRP > 12 mg/L. Non-survivors exhibited an increase in LDH and decreases in PaO₂/FiO₂ ratio and eGFR during the 2nd-3rd week of illness.

Conclusion

The overall mortality rate was high. Predictors of mortality were similar to those of other reports globally. Marked inflammation and worsening pulmonary and renal function were evident among non-survivors by the 2nd-3rd week of illness.

SUBMITTER: Malundo AFG 

PROVIDER: S-EPMC9281405 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature