Ontology highlight
ABSTRACT:
SUBMITTER: Hou R
PROVIDER: S-EPMC9282716 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Hou Ruida R Yu Ying Y Sluter Madison N MN Li Lexiao L Hao Jiukuan J Fang Jie J Yang Jun J Jiang Jianxiong J
Cell reports 20220601 12
Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) promotes tumor cell proliferation, migration, and invasion, fostering an inflammation-enriched microenvironment that facilitates angiogenesis and immune evasion. However, the PGE<sub>2</sub> receptor subtype (EP1-EP4) involved in neuroblastoma (NB) growth remains elusive. Herein, we show that the EP2 receptor highly correlates with NB aggressiveness and acts as a predominant Gα<sub>s</sub>-coupled receptor mediating PGE<sub>2</sub>-initiated cyclic A ...[more]