Alterations of Gut Microbiome and Fecal Fatty Acids in Patients With Polycystic Ovary Syndrome in Central China.

ABSTRACT:

Objective

The purpose of this study was to elucidate the characteristics of the gut microbiome in patients with Polycystic ovary syndrome (PCOS) and analyze the alterations of fecal fatty acid metabolism, so as to further provide the pathogenesis of PCOS.

Methods

Fecal samples from the PCOS group (n = 31) and healthy control group (n = 27) were analyzed by 16S rRNA gene sequencing and untargeted metabolomics. Peripheral venous blood was collected to measure serum inflammation and intestinal permeability. Finally, the correlation analysis of intestinal flora, fecal metabolites, and laboratory indicators was carried out.

Results

Serum D-lactate content in the PCOS group was higher than that in the control group. There was no significant difference in micro

SUBMITTER: Li G 

PROVIDER: S-EPMC9283120 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature