Dataset Information

Cerebral Blood Flow and Oxygen Delivery in Aneurysmal Subarachnoid Hemorrhage: Relation to Neurointensive Care Targets.

ABSTRACT:

Background

The primary aim was to determine to what extent continuously monitored neurointensive care unit (neuro-ICU) targets predict cerebral blood flow (CBF) and delivery of oxygen (CDO₂) after aneurysmal subarachnoid hemorrhage. The secondary aim was to determine whether CBF and CDO₂ were associated with clinical outcome.

Methods

In this observational study, patients with aneurysmal subarachnoid hemorrhage treated at the neuro-ICU in Uppsala, Sweden, from 2012 to 2020 with at least one xenon-enhanced computed tomography (Xe-CT) obtained within the first 14 days post ictus were included. CBF was measured with the Xe-CT and CDO₂ was calculated based on CBF and arterial oxygen content. Regional cerebral hypoperfusion was defined as CBF < 20 mL/100 g/min, and poor CDO₂ was defined as CDO₂ < 3.8 mL O₂/100 g/min. Neuro-ICU variables including intracranial pressure (ICP), pressure reactivity index, cerebral perfusion pressure (CPP), optimal CPP, and body temperature were assessed in association with the Xe-CT. The acute phase was divided into early phase (day 1-3) and vasospasm phase (day 4-14).

Results

Of 148 patients, 27 had underwent a Xe-CT only in the early phase, 74 only in the vasospasm phase, and 47 patients in both phases. The patients exhibited cerebral hypoperfusion and poor CDO₂ for medians of 15% and 30%, respectively, of the cortical brain areas in each patient. In multiple regressions, higher body temperature was associated with higher CBF and CDO₂ in the early phase. In a similar regression for the vasospasm phase, younger age and longer pulse transit time (lower peripheral resistance) correlated with higher CBF and CDO₂, whereas lower hematocrit only correlated with higher CBF but not with CDO₂. ICP, CPP, and pressure reactivity index exhibited no independent association with CBF and CDO₂. R² of these regressions were below 0.3. Lower CBF and CDO₂ in the early phase correlated with poor outcome, but this only held true for CDO₂ in multiple regressions.

Conclusions

Systemic and cerebral physiological variables exhibited a modest association with CBF and CDO₂. Still, cerebral hypoperfusion and low CDO₂ were common and low CDO₂ was associated with poor outcome. Xe-CT imaging could be useful to help detect secondary brain injury not evident by high ICP and low CPP.

SUBMITTER: Svedung Wettervik T

PROVIDER: S-EPMC9283361 | biostudies-literature |

REPOSITORIES: biostudies-literature

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