Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG.

ABSTRACT:

Aims/hypothesis

Individual variation in plasma N-glycosylation has mainly been studied in the context of diabetes complications, and its role in type 1 diabetes onset is largely unknown. Our aims were to undertake a detailed characterisation of the plasma and IgG N-glycomes in patients with recent onset type 1 diabetes, and to evaluate their discriminative potential in risk assessment.

Methods

In the first part of the study, plasma and IgG N-glycans were chromatographically analysed in a study population from the DanDiabKids registry, comprising 1917 children and adolescents (0.6-19.1 years) who were newly diagnosed with type 1 diabetes. A follow-up study compared the results for 188 of these participants with those for their 244 unaffected siblings. Correlation of N-glycan

SUBMITTER: Rudman N 

PROVIDER: S-EPMC9283363 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature