Implicating Causal Brain Magnetic Resonance Imaging in Glaucoma Using Mendelian Randomization.

ABSTRACT:

Background

Glaucoma is hypothesized to originate in the brain but manifests as an eye disease as it possesses the common features of neurodegeneration diseases. But there is no evidence to demonstrate the primary brain changes in glaucoma patients. In the present study, we have used Mendelian randomization (MR) to understand the causal effect of brain alterations on glaucoma.

Methods

Our MR study was carried out using summary statistics from genome-wide associations for 110 diffusion tensor imaging (DTI) measurements of white matter (WM) tracts (17,706 individuals), 101 brain region-of-interest (ROI) volumes (19,629 individuals), and glaucoma (8,591 cases, 210,201 control subjects). The causal relationship was evaluated by multiplicative random effects inverse variance weigh

SUBMITTER: Liu K 

PROVIDER: S-EPMC9283577 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature