Dataset Information

Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer.

ABSTRACT:

Purpose

This research investigated the predictive role of metabolic syndrome (MetS) in breast cancer neoadjuvant chemotherapy (BCNACT) response.

Methods

One hundred fifty primary breast cancer (BC) patients who underwent neoadjuvant chemotherapy (NACT) were included retrospectively. MetS, MetS components [waist circumference (WC), fasting blood glucose (FBG), blood pressure, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)], serum lipid, and other MetS-related laboratory indicators within two weeks before BCNACT were evaluated. Univariate, multivariate, and subgroup analyses were performed to determine the predictors of BCNACT pathologic complete response (pCR), clinical response, and pathologic response. The effectiveness of the model was evaluated via receiver operating characteristic curve (ROC) and calibration curve. External validation was performed through 135 patients.

Results

Univariate analysis revealed that MetS before BCNACT predicted poor BCNACT response (pCR, P = 0.003; clinical response, P = 0.033; pathologic response, P < 0.001). Multivariate analysis confirmed that MetS before BCNACT predicted lower pCR rate (P = 0.041). Subgroup analysis showed that this relationship was significant in estrogen receptor (ER) (-) (RR = 0.266; 95% CI, 0.074-0.954), human epidermal growth factor 2 (HER2) (-) (RR = 0.833; 95% CI, 0.740-0.939) and TNBC (RR = 0.833; 95% CI, 0.636-0.995). Multivariate analysis of external validation confirmed that pretreatment MetS was associated with a lower pCR rate (P = 0.003), and subgroup analysis also confirmed that this relationship had significant statistical differences in ER (-), HER2 (-), and TNBC subgroups.

Conclusions

MetS before BCNACT predicted a lower pCR rate. Intervention on MetS status, especially in ER (-), HER2 (-), and TNBC subgroups, is expected to improve the response rate of BCNACT further.

SUBMITTER: Lu Y

PROVIDER: S-EPMC9284232 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer.

Lu Ying Y Wang Pinxiu P Lan Ning N Kong Fei F Abdumijit Awaguli A Tu Shiyan S Li Yanting Y Yuan Wenzhen W

Frontiers in oncology 20220701

<h4>Purpose</h4>This research investigated the predictive role of metabolic syndrome (MetS) in breast cancer neoadjuvant chemotherapy (BCNACT) response.<h4>Methods</h4>One hundred fifty primary breast cancer (BC) patients who underwent neoadjuvant chemotherapy (NACT) were included retrospectively. MetS, MetS components [waist circumference (WC), fasting blood glucose (FBG), blood pressure, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)], serum lipid, and other MetS-related ...[more]

PMID: 35847887

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Dataset Information

Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer.

Purpose

Methods

Results

Conclusions

Publications

Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer.

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