Unknown

Dataset Information

0

Synthesis and Screening of a DNA-Encoded Library of Non-Peptidic Macrocycles.


ABSTRACT: There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind Streptavidin, a model target, with high affinity.

SUBMITTER: Koesema E 

PROVIDER: S-EPMC9285660 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6957756 | biostudies-literature
| S-EPMC6786493 | biostudies-literature
| S-EPMC2814051 | biostudies-literature
| S-EPMC4837463 | biostudies-literature
| S-EPMC5350604 | biostudies-literature
| S-EPMC7655546 | biostudies-literature
| S-EPMC6393171 | biostudies-literature
| S-EPMC5974701 | biostudies-literature
| S-EPMC5520047 | biostudies-literature
| S-EPMC4571006 | biostudies-other