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Ecological Risk Assessment of Pharmaceuticals in the Transboundary Vecht River (Germany and The Netherlands).

ABSTRACT: Millions of people rely on active pharmaceutical ingredients (APIs) to prevent and cure a wide variety of illnesses in humans and animals, which has led to a steadily increasing consumption of APIs across the globe and concurrent releases of APIs into the environment. In the environment, APIs can have a detrimental impact on wildlife, particularly aquatic wildlife. Therefore, it is essential to assess their potential adverse effects to aquatic ecosystems. The European Water Framework Directive sets out that risk assessment should be performed at the catchment level, crossing borders where needed. The present study defines ecological risk profiles for surface water concentrations of 8 APIs (carbamazepine, ciprofloxacin, cyclophosphamide, diclofenac, erythromycin, 17α-ethinylestradiol, metformin, and metoprolol) in the Vecht River, a transboundary river that crosses several German and Dutch regions. Ultimately, 3 main goals were achieved: 1) the geo-referenced estimation of API concentrations in surface water using the geography-referenced regional exposure assessment tool for European rivers; 2) the derivation of new predicted-no-effect concentrations for 7 of the studied APIs, of which 3 were lower than previously derived values; and 3) the creation of detailed spatially explicit ecological risk profiles of APIs under 2 distinct water flow scenarios. Under average flow conditions, carbamazepine, diclofenac, and 17α-ethinylestradiol were systematically estimated to surpass safe ecological concentration thresholds in at least 68% of the catchment's water volume. This increases to 98% under dry summer conditions. Environ Toxicol Chem 2022;41:648-662. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

SUBMITTER: Duarte DJ

PROVIDER: S-EPMC9290585 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:The pollution of the surface waters by pharmaceuticals and personal care products (PPCPs) has attracted worldwide attention, but data regarding their occurrence and potential risks for the aquatic biota on tropical coastal rivers of South America are still scarce. In this context, the occurrence and the preliminary ecological risk assessment of eleven pharmaceuticals of various therapeutic classes (including cocaine and its primary metabolite, benzoylecgonine) were investigated, for the first time, in five rivers of São Paulo, southeast Brazil, covering a coastline of about 140 km, namely Perequê River, Itinga River, Mongaguá River, Itanhaém River and Guaraú River. Although these five rivers are born in well-preserved areas of the Atlantic rainforest biome, on its way to sea and when they cross the urban perimeter, they receive untreated sewage discharges containing a complex mixture of contaminants. In addition, a "persistence, bioaccumulation and toxicity" (PBT) approach allowed to pre-select the priority PPCPs to be monitored in this coastline. Identification of several PPCPs in the samples was done using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Ten PPCPs were successfully quantified in all five rivers, namely caffeine (9.00-560.00 ng/L), acetaminophen (<LOQ-22.24 ng/L), benzoylecgonine (0.30-14.93 ng/L), atenolol (0.12-13.22 ng/L), losartan (0.10-8.42 ng/L), diclofenac (0.76-3.93 ng/L), cocaine (0.05-3.22 ng/L), furosemide (<LOQ-3.16), carbamazepine (0.04-0.50 ng/L) and orphenadrine (<LOQ-0.14 ng/L). From an ecological risk perspective, caffeine, acetaminophen and losartan can be considered as priority PPCPs because they showed low to moderate risks to algae, crustacean and fishes. However, using the PBT approach, carbamazepine and orphenadrine were also classified as priority compounds, followed by furosemide, acetaminophen, cocaine and losartan (all in second position) and caffeine, atenolol, diclofenac and benzoylecgonine (all in third position). This study provides valuable information to reinforce the importance of continuous monitoring of the coastal rivers of South America (containing PPCPs and illicit drugs) whose diffuse loads flow continuously into the marine ecosystems. Furthermore, ecotoxicological studies (especially with tropical marine organisms) to assess the long-term toxicity of these bioactive compounds are urgent.

Project description:Water is unevenly distributed globally. This uneven distribution is the reason behind the differences among geographical areas in terms of their water footprint of consumption and production. This gives the global trade of goods a unique feature. This characteristic of the water footprint might be used to address water scarcity and conflicts because water availability also has the same trend. Transboundary river basins are freshwater resources with a high probability of water scarcity and conflict because the water is claimed by multiple sovereign countries. In order to design sharing mechanisms for transboundary river basins that incorporate virtual water concept, it is key to identify the virtual water balance of country-basin units. A study addressing this research gap is not yet available. This article identified and discussed net virtual water importer and exporter sub-basins of transboundary rivers at a country-basin mesh based spatial resolution. The results of our study show that out of the 565 country-basin units surveyed in this article 391, 369, and 461 are net gray, green, and blue virtual water importers respectively. These sub-basins covers 58.37%, 47.52% and 57.52% of the total area covered by transboundary river basins and includes 0.65, 1.9, and around 2 billion people, respectively. The results depict that not only the water endowment of sub-basins is a determining factor for their water footprint of consumption and production, but also their social, economic, and demographic profiles. Furthermore, the water footprint of consumption and production within most of the country-basin units have a global feature. Hence, sustainable water management schemes within border-crossing basins should take into account not only the local but also the global water footprints of consumption and production. This can offer more options for sharing transboundary river basins water capital, thereby minimizing the probability of water scarcity and water conflicts.

Dataset Information

Ecological Risk Assessment of Pharmaceuticals in the Transboundary Vecht River (Germany and The Netherlands).

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