Differential effects of speed and volume on transfusion-associated circulatory overload: A randomized study in rats.

ABSTRACT:

Background and objectives

Transfusion-associated circulatory overload (TACO) is the primary cause of transfusion-related mortality. Speed and volume of transfusion are major risk factors. The aim of this study was to investigate the interaction of red blood cell (RBC) transfusion speed and volume on the development of TACO.

Materials and methods

A validated model for TACO in anaemic Lewis rats with an acute myocardial infarction was used. The effect on pulmonary hydrostatic pressure of one, two or four units of packed RBCs transfused in either 30 or 60 min was evaluated (3.3-26.6 ml·kg^-1 ·hr^-1 ). Pulmonary capillary pressure was measured as left ventricular end-diastolic pressure (LVEDP). Cardiac stress biomarkers atrial natriuretic-peptide (ANP) and N-

SUBMITTER: Klanderman RB 

PROVIDER: S-EPMC9291097 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature