Activated CD4⁺ T Cells and Highly Differentiated Alloreactive CD4⁺ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients.

ABSTRACT: Spontaneous operational tolerance to the allograft develops in a proportion of liver transplantation (LT) recipients weaned off immunosuppressive (IS) drugs. Several studies have investigated whether peripheral blood circulating T cells could play a role in the development or identify operational tolerance, but never characterized alloreactive T cells in detail due to the lack of a marker for these T cells. In this study, we comprehensively investigated phenotypic and functional characteristics of alloreactive circulating T cell subsets in tolerant LT recipients (n = 15) using multiparameter flow cytometry and compared these with LT recipients on IS drugs (n = 23) and healthy individuals (n = 16). Activation-induced CD137 was used as a marker for alloreactive T cells upon allogenic stimula

SUBMITTER: Duizendstra AA 

PROVIDER: S-EPMC9291234 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature