Neurodegenerative movement disorders: An epigenetics perspective and promise for the future.

ABSTRACT: Neurodegenerative movement disorders (NMDs) are age-dependent disorders that are characterised by the degeneration and loss of neurons, typically accompanied by pathological accumulation of different protein aggregates in the brain, which lead to motor symptoms. NMDs include Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and Huntington's disease, among others. Epigenetic modifications are responsible for functional gene regulation during development, adult life and ageing and have progressively been implicated in complex diseases such as cancer and more recently in neurodegenerative diseases, such as NMDs. DNA methylation is by far the most widely studied epigenetic modification and consists of the reversible addition of a methyl group to the DNA without chan

SUBMITTER: Murthy M 

PROVIDER: S-EPMC9291277 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature