Antibiotic treatment during early childhood and risk of type 1 diabetes in children: A national birth cohort study.

ABSTRACT:

Objective/background

Antibiotics are widely used during childhood infections and influence the composition of the microbiota, which is established during the first years of life. Evidence from animal models of type 1 diabetes shows that antibiotics might accelerate disease progression, and altered intestinal microbiota has been reported in association with type 1 diabetes in humans. We aimed to test the hypothesis that early exposure to antibiotics (0-24 months of age) was associated with an increased risk of childhood type 1 diabetes development.

Methods

We studied 75 615 mother-child dyads from the Danish National Birth Cohort. Information on the use of antibiotics during early childhood and type 1 diabetes development in childhood was available for all children via linkag

SUBMITTER: Antvorskov JC 

PROVIDER: S-EPMC9291608 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature