Ontology highlight
ABSTRACT:
SUBMITTER: Helmer E
PROVIDER: S-EPMC9292235 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Helmer Eric E Willson Ashley A Brearley Christopher C Westerhof Mark M Delage Stephane S Shaw Iain I Cooke Ray R Sidhu Sharan S
Clinical pharmacology in drug development 20211011 2
Ziritaxestat is a novel inhibitor of autotaxin, an enzyme responsible for the production of lysophosphatidic acid, the downstream signaling of which mediates responses to tissue injury and has been implicated in the pathogenesis of fibrotic conditions such as idiopathic pulmonary fibrosis and systemic sclerosis. This study (Clinical Trial Registration: NCT03787186) was designed to assess the absorption, distribution, metabolism, and excretion of orally administered 600-mg ziritaxestat labeled wi ...[more]