Basomedial amygdala activity in mice reflects specific and general aversion uncontrollability.

ABSTRACT: Learning adaptive behaviour to control aversion is a major brain function. Detecting the absence of control is also important, although chronic uncontrollable aversion can impact maladaptively on stimulus processing in general. The mouse basomedial amygdala (BMA) contributes to aversion processing with high BMA activity associated with active behavioural responding. The overall aim of the present study was to investigate the associations between aversion (un)controllability, BMA activity and behaviour. Fibre photometry of GCaMP6-expressing BMA neuron populations was applied in freely behaving adult male mice during exposure to mild electrical shocks, and effects of specific or general (un)controllability were investigated. In a discrete learned helplessness (LH) effect paradigm, mice under

SUBMITTER: Ineichen C 

PROVIDER: S-EPMC9292353 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature